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6 neighborhoods selected in this guide.

Malá Strana (Lesser Town) is Prague's Baroque quarter, nestled between the castle hill and the river. Its steep cobblestone streets, pastel palaces, embassy gardens, and intimate squares feel like a quieter, more romantic Prague.

Žižkov is Prague's most alternative neighbourhood—rough-edged, pub-filled, and home to the world's largest equestrian statue (Jan Žižka) and the sci-fi-esque Žižkov Television Tower with its crawling baby sculptures.

Holešovice is Prague's creative engine room — a former industrial district reborn as a neighbourhood of galleries (DOX, Vnitroblock), independent cinemas, craft breweries and brunch cafés. The riverside quarter hosts the Prague Market (Pražská tržnice) in a converted slaughterhouse complex.
Vinohrady is Prague's most desirable residential neighbourhood, with tree-lined streets, Art Nouveau facades, excellent restaurants, and a cosmopolitan café scene. It feels like a leafy Central European version of Paris's Marais.

Karlín was devastated by the 2002 Vltava floods and has since reinvented itself as Prague's most forward-looking neighbourhood. Glass-and-steel office buildings sit beside brunch cafés, speciality roasters and coworking hubs, while the remarkable Romanesque-revival Church of Sts.

Josefov is Prague's historic Jewish quarter, a compact area of synagogues, the Old Jewish Cemetery, and Art Nouveau apartment buildings. Once a walled ghetto, it was largely demolished in the 1890s slum clearance but the key religious sites survived.