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7 museums selected in this guide.

The Mucha Museum is dedicated to Alfons Mucha, the Czech Art Nouveau master whose flowing poster designs defined the Belle Époque aesthetic. Located in a Baroque palace, it displays over 100 works spanning his Paris posters to the monumental Slav Epic.

The Czech National Museum's neo-Renaissance building dominates the top of Wenceslas Square, reopened in 2018 after an 11-year renovation. Its natural history, archaeology, and Czech history collections span 14 million objects.
The National Gallery's Trade Fair Palace is a 1928 Functionalist masterpiece housing Czech and international modern art from the 19th century to the present. Six floors cover Impressionism, Cubism (Czech Cubism is uniquely important), and contemporary installations.

The Jewish Museum in Prague comprises six historic sites in Josefov, including four synagogues, the Old Jewish Cemetery, and the Ceremonial Hall. Together they document 1,000 years of Jewish life in Bohemia and one of Europe's most tragically significant Jewish heritage sites.

The Jewish Museum in Prague is a haunting collection of six historic sites — including the Old Jewish Cemetery, four synagogues and the ceremonial hall — that document the 800-year history of Bohemian Jewry. The Pinkas Synagogue's walls are inscribed with the names of 77,297 Holocaust victims.

The Franz Kafka Museum explores the life and literary world of Prague's most famous writer through original manuscripts, first editions, photographs, and immersive audiovisual installations. Located in a Malá Strana riverside building.

The National Technical Museum fills five floors with Czech engineering heritage — from Tatra automobiles and Škoda racing cars to Aero biplanes, printing presses and astronomical instruments. The centrepiece transportation hall is a multi-level showroom of vehicles spanning a century.